We report a case of ocular toxoplasmosis that developed a full-thickness macular hole (FTMH) which was successfully treated by pars plana vitrectomy combined with an inverted internal limiting membrane (ILM) flap.A 49-years-old Japanese man was aware of blurred vision Can Punch / Bottle Openers in his right eye.Slit-lamp biomicroscopy, ophthalmosco
Patients treated in the intensive care unit (ICU) are closely monitored and receive intensive treatment.Such aggressive monitoring and treatment will generate high-granularity data from both electronic healthcare records and nursing charts.These data not only provide infrastructure for daily clinical practice but also can help to inform clinical st
The endoplasmic reticulum aminopeptidase ERAP1 regulates innate and adaptive immune responses by trimming peptides for presentation by major histocompatibility complex (MHC) class I molecules.Previously, we have shown that genetic or pharmacological inhibition of ERAP1 on murine and human tumor cell lines perturbs the engagement of NK cell inhibito
Background: Genome-wide sequencing investigations have identified numerous long noncoding RNAs (lncRNAs) among mammals, many of which exhibit aberrant expression in cancers, including esophageal squamous cell carcinoma (ESCC).Herein, this study elucidates the role and mechanism by which LINC01419 regulates the DNA methylation of glutathione S-trans
OBJECTIVES: Family members of patients in a vegetative state have relatively high rates of anxiety and distress.It is important to recognize the problems faced by this population and apply psychological interventions to help them.This exploratory study describes the psychological stress experienced by family members of patients in a vegetative stat